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KMID : 0359720090270010049
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Journal of the Korean Neurological Association
2009 Volume.27 No. 1 p.49 ~ p.53
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Is Antipsychotic Intake a Risk Factor for the Restless Legs Syndrome?
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Nam Hyun-Woo
Kwon Hyung-Min
Hong Yoon-Ho
Cho Jin-Whan
Cha Jeong-In
Jung Hee-Yeon
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Abstract
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Background: Restless-legs syndrome (RLS) is known to be caused by dopaminergic hypofunction in the brain. We investigated whether antipsychotics that act as antidopaminergics increase the risk of RLS.
Methods: We prospectively recruited 72 schizophrenic patients who had been medicated with antipsychotic drugs in a psychiatry clinic. We evaluated RLS diagnostic criteria and basic sleep habits using the Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index by face-to-face interviews using a structured questionnaire. We also applied the Unified Parkinson’s Disease Rating Scale to evaluate extrapyramidal symptoms.
Results: Three of the 72 patients (4.2%) met RLS criteria, which is similar to the previously reported RLS incidence among the general population in Korea.
Conclusions: There is no evidence that antipsychotics increase the risk of RLS. We believe that the mild antidopaminergic effect of antipsychotics does not overwhelm their prominent antipsychotic effect.
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KEYWORD
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Antipsychotic, Schizophrenia, Restless-legs syndrome, Dopaminergic system
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